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The incidence of LCH is reported to be 3‐5/million; the majority of patients are children younger than 3 years and the incidence in adults is approximately 1‐2/million. 6 Incidence appears to be higher in Caucasians in northern European countries, and lower in Asia and Africa. 7. Jun 15,  · Cladribine is an antimetabolite that uniquely destroys resting and dividing lymphocytes equally It is also potently toxic to monocytes,13 which may explain its potential application to the treatment of monocyte-derived neoplasms and chronic inflammatory conditions, like multiple sclerosis, 27 A further potential mechanism of action of cladribine in LCH may be through T-cell depletion, as cladribine Cited by:

Thus, cladribine has major activity in adult LCH and warrants further investigation in both pediatric and adult LCH as a single agent and in combination with other drugs. Saven A, Burian C () Cladribine activity in adult Langerhans cell histiocytosis. Blood Adam Z, Szturz P, Duras J, Pour L, Kreji M, et al. () Treatment of Langerhans cell histiocytosis by cladribine reached long-term complete remission in 9 out of 10 adult patients. Klin Onkol Author: Marlies E.H.M. van Hoef.

Langerhans-cell histiocytosis (LCH) results from the accumulation of tissue histiocytes derived from the same progenitor cells as monocytes. Because cladribine is potently toxic to monocytes, we conducted a phase II trial of cladribine. Cladribine was administered to 13 LCH patients at mg/kg per day by 2-hour intravenous infusion for 5 consecutive days, every 4 weeks for a Cited by: Cladribine therapy may be beneficial in advanced forms of pulmonary Langerhans cell histiocytosis, even that with multiple cystic To the Editor: Langerhans cell histiocytosis (LCH) is a group of disorders with variable presentations and outcomes. Children with LCH primarily have bone and multisystem involvement with little .